Tablets for pain in the stomach trimedat. What helps Trimedat? Instructions for use

Thanks

The site provides reference information for informational purposes only. Diagnosis and treatment of diseases should be carried out under the supervision of a specialist. All drugs have contraindications. Expert advice is required!

Trimedat is a drug that regulates the intensity of motor motility of the digestive tract (mainly the intestines) and, accordingly, the speed of the food bolus from the esophagus to the large intestine. Trimedat is used to relieve various symptoms caused by gastrointestinal motility disorders, such as diarrhea or constipation, flatulence, intestinal colic, abdominal pain, cramps, nausea and vomiting.

Varieties, names, forms of release and composition of Trimedat

Currently, Trimedat is available in the following two varieties:

Trimedat;
Trimedat Valens.

These varieties differ from each other only in names, and the indications, contraindications and side effects for both drugs are exactly the same. An additional word in the name of the drug "Trimedat Valenta" was introduced in order to obtain a unique name that differs from others by at least one letter. Such a unique name is necessary for the registration of a medicinal product as a trademark of a plant or factory.

And since the drug called "Trimedat" is produced by the South Korean pharmaceutical corporation "Dae Hau New Pharm Co.", then the right to this name also belongs to her. Therefore, the Russian pharmaceutical company "Valenta" began to produce the drug under the name "Trimedat Valenta", which differs from the original by an additional word and is its own trademark.

However, since, in fact, the preparations Trimedat and Trimedat Valenta are varieties of the same drug, we will use the common name "Trimedat" to refer to them in the further text of the article.

Trimedat is available in a single dosage form - oral tablets. There are two dosage options for the active substance - 100 mg or 200 mg per tablet. That is, Trimedat is available in tablets with two dosages - 100 mg and 200 mg.

As an active ingredient Trimedat contains trimebutine. As auxiliary components The tablets of both dosages contain the following substances:

Silicon dioxide colloidal;
Corn starch;
magnesium stearate;
Talc.

Tablets of both dosages (100 mg and 200 mg) are available in packs of 10, 20 and 30 pieces.

South Korean-made Trimedat tablets with a dosage of 100 mg are flat-cylindrical in shape, painted white and equipped with two embossed letters "TM" on one side and two intersecting risks on the other. Three triangles are visible above and below the letters "TM", located on the same line.

South Korean-made Trimedat tablets with a dosage of 200 mg have a round, biconvex shape, are painted white, and are also provided with a risk on one side and an extruded symbol in the form of two drops on the other.

Trimedat Valenta tablets of both dosages have the same shape and color - round flat-cylindrical, painted white. Tablets of 100 mg are provided on one side with a chamfer, and on the other with two intersecting risks. Tablets of 200 mg are provided with one facet and a risk from different sides.

Action Trimedat

The therapeutic effect of Trimedat is to equalize the intensity of peristaltic movements and contractions in all parts of the intestine, due to which the food bolus moves evenly, at an optimal speed, without stopping anywhere and, at the same time, without slipping too quickly. Due to the normalization and equalization of the speed of movement of the food bolus in various parts of the intestine, the problem of symptoms of digestive disorders caused by various diseases of the stomach and intestines, such as increased gas formation (flatulence), bloating, abdominal pain, cramps, intestinal colic, diarrhea or constipation, is completely eliminated. as well as nausea and vomiting.

Thus, the action of Trimedat ensures the elimination of painful symptoms accompanying diseases of the stomach and intestines or their functional disorders (for example, after taking a large amount of fatty, spicy, spicy or other irritating food, etc.). Therefore, Trimedat is used as a symptomatic medicinal product for the relief of painful manifestations of diseases of the intestines and stomach.

The specified therapeutic effect of Trimedat is achieved by its ability to normalize the intensity of peristaltic contractions of the intestine, that is, to accelerate with insufficiency and reduce with redundancy. In addition, the drug acts as antispasmodic, reducing tension and too strong tone of the smooth muscles of the intestine, which contributes to the relief of spastic pain.

That is, Trimedat restores the intensity of movements of the smooth muscles of the intestine in various diseases, thereby normalizing the process of digestion and eliminating the painful symptoms of intestinal dyspepsia (flatulence, diarrhea or constipation, bloating, spastic pain).

The advantage of the drug is that Trimedat just normalizes intestinal motility, that is, increases or decreases its intensity, depending on the existing level in relation to the norm.

In addition, Trimedat optimizes the pressure of the esophageal sphincter and the rate of gastric emptying, which eliminates reflux of gastric contents. Stopping reflux, in turn, eliminates such unpleasant symptoms as nausea, vomiting and heartburn.

Indications for use

Trimedat tablets are indicated for use in the following cases:

Irritable bowel syndrome, accompanied by abdominal pain and colic, intestinal cramps, flatulence, diarrhea or constipation (or their alternation);
Postoperative paralytic ileus;
Gastroesophageal reflux disease (GERD);
Dyspeptic symptoms in functional disorders of the gastrointestinal tract associated with impaired motor skills, such as swallowing air during meals, discomfort or pain in the stomach, a feeling of fullness or fullness in the stomach after eating, rapid satiety;
Dyspeptic disorders against the background of diseases of the stomach and intestines, such as flatulence, bloating, diarrhea or constipation (or their alternation), cramps and pain in the abdomen, nausea, vomiting;
Preparation for x-ray or endoscopic examination of the stomach or intestines;
Dyspeptic symptoms in children (nausea, vomiting, diarrhea, constipation, flatulence, bloating, abdominal cramps and pain) associated with impaired motility of the gastrointestinal tract.

Trimedat - instructions for use

How to take Trimedat?

Trimedat tablets should be taken orally, swallowed whole, without biting, chewing or crushing in other ways, but with a sufficient amount of water (it is optimal to drink tablets with 2/3 cup of water).

The dosage of Trimedat is the same for various diseases, but differs for children and adults. Currently, it is recommended to take Trimedat in the following dosages depending on age:

Teenagers over 12 and adults

In the indicated age dosages, Trimedat should be taken in the presence of any indication. The duration of the course of use depends on the disease or condition for which the drug is taken.

So, for the treatment of irritable bowel syndrome, you should take Trimedat in acute period 200 mg 3 times a day for four weeks. Then, to prevent relapses and achieve stable remission at the end of 4 weeks, you should continue taking Trimedat already at a dosage of 100 mg 3 times a day for 12 weeks in a row. Such a therapy regimen: 4 weeks of 600 mg per day + 12 weeks of 300 mg per day allows you to cure irritable bowel syndrome in almost 100% of cases.

People suffering from irritable bowel syndrome in remission can undergo treatment with Trimedat, aimed at preventing relapses, by taking 100 mg tablets three times a day for three weeks.

With functional disorders or diseases of the digestive tract (including cholecystitis, pancreatitis, gastritis, peptic ulcer of the stomach and duodenum, GERD, etc.) Trimedat as a symptomatic drug should be taken in courses lasting 2-3 months for both children and adults . Moreover, it is recommended to repeat the courses of therapy periodically, observing intervals between them lasting at least 3 months. Remember that the effect of Trimedat in chronic diseases develops and manifests itself only by the end of the second week of admission, so short courses of therapy in these cases are useless.

When using Trimedat as an emergency remedy, for example, with symptoms of dyspepsia in children (bloating, belching, nausea, cramps, intestinal colic, etc.), the drug should be given at an age dosage for several days, until the symptoms of the disorder are completely will pass. In the same way, adults can also take Trimedat in short courses when symptoms of dyspepsia appear that are not associated with diseases or functional disorders of the gastrointestinal tract. That is, if a child or an adult has bloating, nausea, colic or abdominal cramps, diarrhea that is not associated with an infectious disease (for example, "bear disease"), or flatulence, then to eliminate these symptoms, you can take Trimedat at an age dosage . In such cases, when the symptoms of dyspepsia occur episodically, and are not constantly present, the drug should be taken in short courses lasting 1 to 3 days.

When preparing for an x-ray or endoscopic examination of the digestive tract, take Trimedat 1-2 times at the age dosage before the upcoming manipulation.

In the treatment of postoperative paralytic ileus, Trimedat must also be taken at an age dosage for at least 4 weeks. After four weeks of treatment, it is necessary to evaluate the motor activity of the intestine, and based on the data obtained, make a decision to stop or continue therapy.

Trimedat - before meals or after?

Tablets are optimally taken 15 to 30 minutes before meals for both adults and children. If for some reason it is not possible to take Trimedat 15-30 minutes before a meal, then this can be done within 20 minutes after a meal. In this mode, tablets should be taken as planned, during the entire course of therapy.

However, if symptoms of dyspepsia (abdominal pain, colic and intestinal cramps) occur between meals, then you can take Trimedat urgently, and not as planned, in which case you do not need to focus on food. That is, the drug can be taken at any time, regardless of meals.

Use during pregnancy and breastfeeding

During experimental studies on animals, Trimedat was not detected negative impact on the fetus and the course of pregnancy. However, for obvious ethical reasons, such trials have not been conducted in pregnant women, so there is no exact data on the safety of the drug. That is why it is not recommended to take Trimedat during the first trimester of pregnancy (from the beginning to the end of the 13th week). And in the II and III trimesters, you can take Trimedat only if the potential benefit outweighs all possible risks.

Since it is not known whether Trimedat penetrates into women's milk, it is recommended to stop using the drug throughout the entire period of breastfeeding. If it is necessary to take Trimedat for health reasons, then the child should be weaned and transferred to artificial mixtures.

Influence on the ability to control mechanisms

Trimedat does not affect the functions of the central nervous system, and therefore, against the background of its use, you can engage in any type of activity that requires a high speed of reactions and concentration of attention.

Overdose

An overdose of Trimedat tablets has not been detected even once during the entire period of observation of its clinical use.

Interaction with other drugs

Interaction with other drugs for Trimedat is not described. This means that Trimedat can be combined with any other drugs needed to effectively treat various diseases and conditions.

Trimedat for children

Trimedat can be used to eliminate the symptoms of dyspepsia in children provoked by various causes. You should know that South Korean-made Trimedat can be used for children only from the age of 12, and the Russian Trimedat Valenta - from 3 years.

Most often, Trimedat in children of different ages is used for symptoms of dyspepsia that are not associated with any diseases, such as:

Abdominal pain;
Discomfort, feeling of heaviness or fullness in the stomach;
Nausea;
Colic and spasms of the intestines;
Flatulence;
Bloating
Constipation;
Diarrhea not associated with an infectious disease or poisoning).

In children of different ages, the listed symptoms of dyspepsia can occur quite often for a variety of reasons, for example, after drinking unusual food or a large amount of carbonated water, overeating, intense physical exertion after eating, against the background of nervous tension, climate change or unusual surroundings, etc. Regardless of the cause that provoked the phenomena of dyspepsia, Trimedat can be used to stop them in children. In such cases, tablets should be given at the age dosage for 1 to 3 days. Stop using the drug should be after the complete disappearance of symptoms of dyspepsia.

Since dyspeptic symptoms develop quite often in children, Trimedat is a necessary drug in any home or travel first aid kit, as it quickly normalizes the child's condition, stopping painful symptoms.

In addition, Trimedat can be used as part of the complex therapy of various diseases of the digestive tract in children, such as GERD, gastritis, gastroduodenitis, pancreatitis, etc. In such situations, Trimedat should be given to the child at an age dosage in long courses of 1 to 3 months.

The dosage of Trimedat for children depends only on their age, and is the same for various conditions and diseases. This means that for any disease or condition, the child should be given Trimedat in the same dosage appropriate for his age.

Teenagers over 12 years old- take 100 - 200 mg 3 times a day;
Children aged 6 - 11 years inclusive- take 50 mg (half a tablet with a dosage of 100 mg) three times a day;
Children aged 3 - 5 years inclusive- take 25 mg (a quarter of a tablet with a dosage of 100 mg) three times a day.

Tablets can be given to a child regardless of food intake, especially if it is necessary to eliminate sudden symptoms of dyspepsia that are not associated with any diseases of the digestive tract.

Adolescents over 12 years of age are given whole tablets of the required dosage (100 mg or 200 mg), which they must swallow whole and drink clean non-carbonated water. For children aged 3 to 11 years, Trimedat 100 mg tablets must be divided into two or four parts to obtain a dose of 50 mg or 25 mg. After the tablet is divided into the required number of parts, you can give the child the required dosage in two ways. First, you can let the baby swallow half or a quarter of the pill, if he already knows how to do it. Secondly, you can grind half or a quarter of the tablet into powder, place it in a spoon, add a little water and let the child drink the resulting suspension.

The choice of the method of taking Trimedat tablets by children aged 3 to 11 years depends on their preferences. That is, if it is more convenient for a child to swallow tablets, then you should give him a half or a quarter. If the child swallows tablets with difficulty and is accustomed to liquid dosage forms (syrups, suspensions, solutions), then it is better to crush half or a quarter of Trimedat into powder, then dissolve it with water, turning it into a suspension, and give it to the baby in this form.

Trimedat for constipation

Trimedat has a regulating effect on intestinal motility, strengthening or, on the contrary, weakening it, depending on the need and the initial level available. Moreover, in different parts of the intestine, Trimedat can have exactly the opposite effect - for example, in the small intestine it increases peristalsis, and in the large intestine, on the contrary, it weakens, or vice versa. Such a therapeutic effect of the drug leads to the fact that intestinal motility is normalized and synchronized, as a result of which the food bolus moves at an optimal speed, which ensures complete digestion. Accordingly, ensuring optimal peristalsis normalizes defecation, eliminating both constipation and diarrhea. That is why Trimedat can be used to treat both constipation and diarrhea (non-infectious origin).

For constipation, Trimedat for adults and adolescents over 12 years of age is recommended to take 100 mg 2 to 3 times a day 15 to 20 minutes before meals. Babies 3-5 years old with constipation should be given Trimedat 25 mg 2-3 times a day, and children 6-11 years old - 50 mg 2-3 times a day, also 15-30 minutes before meals. The duration of therapy depends on the rate of normalization of the defecation process. That is, you should take the pills until the stool becomes regular.

Individual sensitivity or allergic reactions to any components of the drug;

I trimester of pregnancy (until the end of the 13th week of gestation);

Lactase deficiency, lactose intolerance, glucose-galactose malabsorption.

Trimedat - analogues

The entire set of analogues of any drug, including Trimedat, is divided into two large groups - these are synonyms and, in fact, analogues. Synonyms are medications containing the same active substance. That is why synonyms are also called structural analogs.

Analogues are drugs that have the most similar spectrum therapeutic action but containing various active substances. Such drugs are often referred to as "analogue drugs".

Synonyms of Trimedat are drugs that also contain trimebutine as an active substance. On the domestic pharmaceutical market, there are the following preparations-synonyms of Trimedat:

Debridate solution (available in some CIS countries and Europe);
Neobutin tablets;
Tributate tablets (available in Ukraine);
Trimspa 200 tablets (only available in Ukraine and Kazakhstan).

Analogues of Trimedat are drugs containing other active substances, but also with the ability to regulate intestinal motility. Currently, the following drugs are classified as Trimedat analogues:

Dicetel tablets;
Duspatalin capsules;
Iberogast drops for oral administration;
Colofort lozenges;
Niaspam capsules;
Pepsan-R capsules and gel for oral administration;
Spazmomen tablets;
Sparex capsules;
Trigan solution for injection;
Enterosan capsules.

And excipients: corn starch, colloidal dioxide silicon, lactose, talc, magnesium stearate.

Release form

The drug is available in tablet form, in a package of 10, 20, 30 pieces.

pharmachologic effect

Myotropic antispasmodic that regulates motility digestive system . The active substance acts on the enkephalinergic system of the intestine, regulates peristalsis . Trimebutine has an antispasmodic effect in hyperkinesis of the smooth muscle tissue of the digestive tract, and in hypokinetic conditions it stimulates the intestines.

The drug enhances peristalsis and promotes emptying stomach , reduces pressure on esophageal sphincter , acts throughout the intestine, enhances the response of the smooth muscle tissue of the large intestine to various food stimuli.

Author-compiler:- doctor, medical journalist Speciality:Cardiology, Functional diagnostics, Otorhinolaryngology

Education: She graduated from the Bashkir State Medical University with a degree in General Medicine. In 2011 she received a diploma and a certificate in Therapy. In 2012 she received 2 certificates and diplomas in "Functional Diagnostics" and "Cardiology". In 2013, she took courses on "Actual Issues of Otorhinolaryngology in Therapy". In 2014, she completed advanced training courses in the specialty "Clinical Echocardiography" and courses in the specialty "Medical Rehabilitation".

Work experience: From 2011 to 2014 she worked as an internist and cardiologist at MBUZ Polyclinic No. 33 in Ufa. Since 2014, she has been working as a cardiologist and functional diagnostics doctor at Polyclinic No. 33 in Ufa.

NOTE! Information about medicines on the site is a general reference, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medicines in the course of treatment. Before medicine use Trimedat surely consult with the attending physician.

Maya | 12:40 | 10.08.2018

I had colitis, although I endured pain for a long time and did not go to the doctor. Where was my mind? I don't know... I drank the course of Trimedat and forgot about the pain and discomfort in my stomach. And why not immediately go and solve this issue? Don't repeat my mistakes!

Glasha | 18:46 | 28.04.2018

Good tablets. I take them on vacation all the time so as not to spoil it. In ordinary life I keep proper nutrition, and on trips, especially in other countries, I allow myself slack, but somewhere I eat exotic dishes, well, then there are troubles with the stomach. And trimedat solves them all. It is convenient that you do not need to drink different means, one is enough to rest in peace.

Marina | 13:27 | 10.04.2018

Trimedat helped me, good pills and inexpensive. Now no hint of constipation.

Daria Ustinova | 12:18 | 19.01.2018

With my work, I eat normally once a day, otherwise I don’t have time to eat snacks, and as a result, the stomach throws up surprises. There is no time to go to the doctors, I consulted with the pharmacist, she recommended drinking trimedat as the instructions say. Did. Helped. I think if again there will be surprises from the stomach or intestines, I will drink another course, this is better than getting into an uncomfortable position in society.

Olga | 21:39 | 02.08.2017

I didn’t know about this drug before, but faced with spasms and nausea, I went to the doctor, but they didn’t find anything serious on gastroscopy, but they said to be careful, as there is irritation. They prescribed me a diet and trimedat. A week later there were no more problems, but it was ordered to conduct a course and I drank it up to 30 days, 3 packs. Everything is now normal.

Trimedat is a long-acting drug. His beneficial features aimed at improving the functioning of the stomach and intestines. It contains the substance trimebutin. The analogues of the drug are:

motilium
noubutin

style="color: #000000">How does trimedat work?

After you have taken a tablet of this medicine, it is quickly absorbed by the walls of the stomach, and after an hour and a half it begins to have a therapeutic effect. He finishes helping in 5 hours. That is why it is recommended to drink it three times a day. The drug acts not only in the stomach, but throughout the intestinal tract. Excreted from the body during urination.

This medicine normalizes the ability of the stomach muscles to contract by irritating their epithelium (upper, villous, mucous layer).

It also reduces the pressure of the upper stomach and regulates the normal (daily) excretion of feces from the intestines.

It also reduces and stops colic, blocks pain, bloating and increased gas formation.

Sometimes doctors, if necessary, prescribe complex treatment. Then, together with this substance, they are prescribed

mezim,
festal,
omez,
creon,
gastal,
rennie,
almagel,
phosphalugel, etc.

style="color: #000000">What does trimedat look like in tablets?

Trimedat tablets

The drug is produced in tablet form., Dosages of 100 milligrams. and 200 milligrams.
Tablets of 100 milligrams. white color, have an elongated oval shape. Embossed letters TM in the middle. and be a dividing line, to improve usability.
Tablets of 200 milligrams of white color have the shape of a biconvex circle.

style="color: #000000">To whom is trimedat assigned? How to take it?

The drug is prescribed for adults, the elderly and children over 3 years of age. But in individual cases trimedat is prescribed for children and younger children.
Children from 3 to 5 years old are recommended to use this remedy at a dose of 25 milligrams three times a day.
Children from 4.5 to 11.5 years old are prescribed a dosage of 50 milligrams three times a day

Adults are prescribed 100 milligrams three times a day. In severe disease and postoperative period the dose may be increased to 200 milligrams three times a day.
Food does not enter the stomach immediately. In the beginning, it comes through the pharynx, esophagus. It takes time. It should be taken 15-20 minutes before meals with a small amount of warm water. By the time the food reaches the stomach, the drug will already begin to act.

style="color: #000000">What is trimedat taken from? Who appoints him

Only an experienced gastroenterologist can prescribe trimedat. It is to him that you should turn if you feel unwell, heaviness and burning, pain in the stomach or intestines. Only a doctor can prescribe the correct and effective treatment which will help to overcome the disease. After the examination and a series of tests, the doctor makes a diagnosis. Symptoms can occur with the following diseases: gastritis, colitis, postoperative therapy, stomach or intestinal ulcers (narrowing of its ducts or vice versa, their strong expansion or increase in the volume of bile produced, gallstones), absence of the gallbladder (due to its removal during during surgery) or other various diseases of the stomach and intestines. Trimedat is also prescribed after severe poisoning. In preparation for an endoscopic analysis, doctors often prescribe a course of treatment with this drug. After surgery, patients often suffer from severe constipation. Feces stagnate in the intestines. In these cases, it is also recommended to drink trimedat.

During the course of treatment with this remedy, during an exacerbation of the disease, it is recommended to adhere to a diet. You should give up strongly fried, spicy, fatty foods, as well as flour products and fresh vegetables and fruits. After the peak of the attack is suppressed, you can return to the usual menu.

style="color: #000000">Symptoms of the above diseases

Stomach ache

In connection with violations of the digestive tract, the patient experiences severe discomfort. Foods eaten are poorly digested and absorbed. Because of this, their absorption and digestibility by the whole organism as a whole is disturbed. In this case, the patient may experience heartburn, vomiting, softening or fixing stool, weakness, bloating and increased gas formation appear. There is a constant feeling of a heavy stomach. Moreover, it doesn’t matter at all that you ate a meat chop or an apple. You may feel like you constantly want to go to the toilet. During trips to the toilet, a person experiences an unpleasant burning sensation in the anus (anus irritation, redness and itching appear) .. There is a strong, cutting pain in the stomach and below.

style="color: #000000">Trimedat contraindications

This drug is practically harmless. It can be used according to the instructions for almost everyone, with the exception of children under three years of age (there are exceptions), and people suffering from severe allergic reactions and who are allergic to the components of the drug.

style="color: #000000">Can I take Trimedat while breastfeeding?

Everyone has long known that nutrients, vitamins, microelements, along with mother's milk, are transferred to the child. Harmful toxic substances and drugs are no exception. And since trimedat is not recommended for children under three years of age, it is also contraindicated for nursing mothers to take it. In rare cases, doctors prescribe this drug to nursing mothers (if the benefits of taking it outweigh the risk to the child). At the same time, if possible, it is recommended to stop breastfeeding the baby for a while.

style="color: #000000">Can I take trimedat during pregnancy?

You can, with the exception of the first trimester. At this time, the formation of the main organs and senses in the embryo occurs. And since the harm of the drug to the fetus during this period has not been studied. not worth the risk again. In the second and third trimester of pregnancy, trimedat can be taken according to the usual scheme according to the attached instructions. It should be noted that the body of a pregnant woman is more sensitive to external and internal stimuli. Even if you have been taking this drug for a long time and have not observed any side effects before, trimedat during this period can cause allergic reactions, skin redness and itching.

There are also folk methods treatment of these diseases. But they usually require long-term use, spend a lot of time and are less effective and efficient than trimedat. Plus, not every person will be able to choose the right proportions of herbs and drugs and make them correctly.

This drug is available in free form in pharmacies (no prescription required). The average cost per package of the drug 200 milligrams No. 30 ranges from two hundred and fifty to three hundred rubles. For a package of medicine 100 milligrams No. 30, you will give from one hundred and fifty to one hundred and ninety rubles. If you found this medicine at a lower price on the windows of pharmacies, you should be wary, but is everything in in perfect order with expiration dates and whether it corresponds to the qualities. If a drug is overpriced, you can refer to the drug price registry. This is a large list of all medicines and biological supplements manufactured and produced in Russia. It specifies the allowable minimum prices and the maximum allowable mark-ups for drugs.

Dear readers, remember that any disease is much easier to prevent than to treat it later. If you experience any of the above symptoms, you should immediately consult an experienced doctor. Only a doctor, after conducting all the necessary studies and prescribing a series of tests, will be able to prescribe the correct and effective treatment. Trimedat should also be taken under the supervision of the attending physician. Do not self-medicate. This will not only not improve your well-being, but will also provoke deterioration. general condition, which in turn will lead to serious complications, such as intestinal and stomach ulcers, and even oncological diseases. Carefully monitor your health, eat right and regularly, give up bad habits. But even if you have a need to take the drug triedat, then follow the exact dosage regimen, according to the instructions and recommendations of your doctor. Be healthy and all the best to you!

Trimedat (active ingredient trimebutin) is a domestic drug from the pharmaceutical company Valenta, the main pharmacological function of which is the regulation of motility of the gastrointestinal tract (GIT). It is used for various functional diseases of the digestive system, dyspeptic disorders, as well as for so common in recent times irritable bowel syndrome (its universal markers are abdominal pain and colic, intestinal cramps, increased flatulence, diarrhea or constipation). Trimedat acts throughout the digestive tract, including the bile ducts along with the gallbladder. In clinical practice, it is not uncommon for patients to have diverse motor disorders of the gastrointestinal tract, with a predominance of various pathogenetic components. To identify a specific type of disorder, instrumental studies are complex and not always available for a wide range of patients, such as: endoscopic manometry of the sphincter of Oddi, examination of the motor function of the digestive tract with radioactive gold, etc. The lion's share of motor dysfunctions have a complex pathogenesis, therefore, in the arsenal of a gastroenterologist, there simply must be drugs that can favorably affect motor skills, regardless of what type of violation occurs in this particular case. Trimedat is one of these medicines. It eliminates both hypomotor and spastic dyskinesia of the intestine and biliary tract. Such universalism of trimedate makes it possible to influence the pathological process even at its very initial stage and reduce the volume of necessary diagnostic interventions (as well as their cost, of course).

The substance trimebutine was synthesized in France in 1969 and long years was known under the trade name debridat.

In 2008, the Russian pharmaceutical company Valenta entered the market with its new brainchild, the drug trimedat, which was created on the basis of trimebutine. Trimedat enters into interaction with peripheral opiate receptors, "scattered" throughout the gastrointestinal tract. They are located mainly in the nerve plexuses of the intestine. In the series of opiate receptors, there are 3 subspecies mu-, delta- and kappa. The first two are responsible for conducting excitation, and the last one is responsible for inhibition. Trimedat does not have an affinity for any one subspecies of receptors, interacting with all at once. Being a normokinetic, it has a dual regulatory effect. By binding to kappa receptors, trimedat inhibits motility, and by performing the same action on mu and delta receptors, it stimulates it. Thus, trimedat, depending on the circumstances (read: the initial state of the motor function of the digestive tract), can act both as an antispasmodic and as a prokinetic. Trimedat affects the humoral regulation of the digestive organs, increasing the level of motilin (this hormone is one of the main regulators of gastrointestinal motility), reducing the level of gastrin, insulin, glucagon, pancreatic polypeptide, vasoactive intestinal peptide. As a result, the following clinically significant effects are modulated: gastric evacuation is accelerated, the motor function of the large intestine and visceral sensitivity change. The effectiveness of trimedat has been proven in a number of randomized trials. For example, in the treatment of irritable bowel syndrome, it was about 83%, which allows us to consider this drug as a universal regulator of the motor function of the gastrointestinal tract.

Pharmacology

Trimebutin, acting on the enkephalinergic system of the intestine, is a regulator of its peristalsis. Possessing an affinity for excitation and suppression receptors, it has a stimulating effect in hypokinetic states of the smooth muscles of the intestine and antispasmodic in hyperkinetic ones.

The drug acts throughout the gastrointestinal tract, reduces the pressure of the esophageal sphincter, promotes gastric emptying and increased intestinal motility, and also promotes the response of the smooth muscles of the colon to food stimuli.

Trimebutin restores the normal physiological activity of the intestinal muscles in various gastrointestinal diseases associated with motor disorders.

Pharmacokinetics

Suction

After oral administration, trimebutine is rapidly absorbed from the gastrointestinal tract. Cmax in blood plasma is reached after 1-2 hours. Bioavailability is 4-6%.

Distribution

The degree of binding to plasma proteins is low - about 5%. Vd - 88 l. Trimebutin to a small extent penetrates the placental barrier.

Metabolism

Trimebutin is biotransformed in the liver.

breeding

Trimebutine is excreted in the urine mainly as metabolites (approximately 70% during the first 24 hours). T 1/2 - about 12 noon

Release form

Tablets are white, flat-cylindrical, with a symbol embossed on one side in the form of the letters "TM", above and below which are located in a line of three triangles; on the other side are two intersecting risks.

Excipients: lactose, colloidal silicon dioxide, talc, corn starch, magnesium stearate.

10 pieces. - cellular contour packings (1) - packs of cardboard.
10 pieces. - cellular contour packings (2) - packs of cardboard.
10 pieces. - cellular contour packings (3) - packs of cardboard.

Dosage

For adults and children over 12 years of age, the drug is administered orally at 100-200 mg 3 times / day. To prevent recurrence of irritable bowel syndrome after a course of treatment during remission, it is recommended to continue taking the drug at a dose of 300 mg / day for 12 weeks.

Children aged 5-12 years are prescribed 50 mg 3 times / day, children aged 3-5 years - 25 mg 3 times / day.

Overdose

To date, cases of overdose of the drug Trimedat ® have not been reported.

Interaction

The drug interaction of the drug Trimedat ® is not described.

Side effects

Rarely: skin reactions.

Indications

gastroesophageal reflux disease;
motor disorders in functional diseases of the gastrointestinal tract;
dyspeptic disorders in gastroduodenal diseases (abdominal pain, indigestion, nausea, vomiting);
irritable bowel syndrome, manifested by pain, colic in the abdominal cavity, intestinal cramps, flatulence, diarrhea and / or constipation;
postoperative paralytic ileus;
preparation for x-ray / endoscopic examination of the gastrointestinal tract;
dyspeptic disorders in children associated with impaired motility of the gastrointestinal tract.

Trimedat has become a widely used drug. It is used to treat adults and children with colic and digestive disorders. It compares favorably with other antispasmodics, which is why it has received recognition from gastroenterologists. From what the drug helps and how to use it correctly, you will learn from this article.

Composition and form of release

The action of Trimedat is due to the presence of trimebutine in the composition. The remaining substances are auxiliary and do not have a pharmacological effect:

talc;
magnesium stearate;
silicon dioxide colloidal;
corn starch.

The drug is produced only in tableted flat-cylindrical form. Tablets are white, with the letters "TM" embossed on one side.

The dosage of the main active ingredient per 1 tablet is 100 mg or 200 mg.

In pharmacies, the drug can be found under two names Trimedat and Trimedat Valenta. These drugs do not differ in their constituent components. Their difference lies in the country of manufacture:

Trimedat Valenta - produced in Russia;
Trimedat - made in the Republic of Korea.

pharmachologic effect

The main pharmacological action of the drug is antispasmodic. In this case, the effect is observed throughout the entire intestine.

Preparation Trimedat:

helps with difficult bowel movements;
I contribute to the promotion of feces in the large intestine;
reduces the tone of the esophageal sphincter.

The active substance trimebutine affects the receptors for excitation and suppression of the smooth muscles of the intestine. Therefore, it is able to bring the physiological activity of the digestive tract back to normal in violation of its motility. In addition, the reaction to food stimuli is restored.

Indications for use

Due to its effect on the body, Trimedat tablets help to cope with indigestion in the following conditions:

gastroesophageal reflux (ingestion of stomach contents into the lower esophagus);
dyspepsia of various origins (caused by diseases of the gastrointestinal tract or functional, due to the use of an excess amount of "harmful" food);
irritable bowel syndrome;
motor disorders in diseases of the digestive tract;
violation of bowel movements (constipation or diarrhea);
abdominal pain, nausea, vomiting, flatulence that occurs after eating;
violation of intestinal patency after surgery;
to prepare for endoscopic manipulations and X-ray examinations.

How to take Trimedat

Taking the drug should be started only after consulting a doctor. This is necessary to exclude the presence of diseases in which there is a possibility of aggravation side effects. This is especially true for long-term therapy, since a single use does not have such risks.

According to the instructions for use, the drug Trimedat is taken at a dosage of 100 or 200 mg (1-2 tablets) by adults and children (from 12 years old) 3 times a day.
Children from 5 to 12 years old are recommended to divide the tablet (100 mg) in half and give one half (50 mg) 3 times a day.
At the age of 5 years, the child is given 1/4 tablet with a dosage of 100 mg three times a day.

The maximum dose that does not lead to undesirable effects is 600 mg per day.

The tool is also used in the absence of severe symptoms (remission) of irritable bowel syndrome. It helps to stabilize the condition and prevents the development of a relapse of the disease. In this case, the dosage should not exceed 300 mg per day. The course of therapy is 3 months.

The effectiveness of Trimedat does not depend on the presence of food in the stomach. Therefore, you can drink it both before meals and after taking any liquid or food.

Tablets are recommended to drink only clean filtered water. Since in direct contact with other liquids there is a possibility of a chemical reaction, which at best will lead to inactivation of the main active substance.

Important! Trimedat is incompatible with alcohol. The intake of ethanol-containing drinks leads to a slowdown in metabolic processes in the liver, as a result, the activity of trimebutine decreases. This leads to a lack of therapeutic effects on the body.

Application in childhood

In order not to be mistaken in the possibility of using the drug in childhood, it is important to carefully read the information about the country of the manufacturer:

Trimedat produced in Korea is not recommended for use by persons under 12 years of age.
The drug of domestic production is contraindicated in children under 3 years of age. But this point requires detailed consideration, since in practice parents often face the appointment of the drug at an earlier age.

Trimebutine, which is part of the composition, is safe for use in infancy. But since its dosage form is tablets, it cannot physically be taken by a small child. That is, the contraindication refers specifically to the release form, and not to the active compound.

Therefore, pediatricians and gastroenterologists advise crushing the tablet and adding a small amount of water. And give the already received suspension to the baby. The doctor should calculate the dose and how to properly dilute the drug (how many ml of liquid to add), as this will depend on age and weight.

Most often, for children from six months, Trimedat is prescribed to eliminate difficulty in emptying the large intestine (constipation) against the background of the introduction of complementary foods (0.5-1 teaspoon 2-3 times a day).

Use during pregnancy and breastfeeding

Trimedat is not officially approved for use during pregnancy, as clinical trials have not been conducted on pregnant women (for ethical reasons). Therefore, there are no reliable data on the safety of the drug.

But laboratory experiments on animals indicate the absence of embryotoxic and teratogenic effects on the fetus. Therefore, the appointment of the drug can be found in the second and third trimester. But only a doctor can recommend it for use.

Attention! In the first trimester (up to 12 weeks) of pregnancy, it is not recommended to use Trimedat, like other medicines. After all, it is during this period that the formation of all organs and systems of the fetus takes place. Therefore, any minimal interference from the outside can lead to a violation in the development of the child.

Doctors do not know the degree of penetration of trimebutine into breast milk. Therefore, if necessary, treatment during the period breastfeeding it is worth switching the baby to adapted milk formulas for baby food or stop breastfeeding (if the baby's age allows).

Interaction with other drugs

There are no exact data on the mutual influence of Trimedat and other drugs on each other.

In some cases (not on a permanent basis), an increase in the duration of the anticholinergic effect of zotepine has been noted.
In addition, several precedents for the lengthening of the effect of d-tubocurarine have been registered.

Contraindications

The use of the drug should not be started if an allergic reaction is detected both to the active substance and to auxiliary components.

Also, a contraindication will be the impossibility of taking this dosage form:

swallowing disorder;
problems with the maxillofacial apparatus;
breast age.

In these cases, the use of tablets is possible only in crushed form.

Side effects

Trimedat is most often well tolerated, but sometimes there are side effects that are not regular (that is, they occur singly in some people):

violations menstrual cycle in various manifestations (increase in the duration of bleeding, reduction or increase in the total cycle);
hearing impairment;
allergic reactions of varying intensity, depending on the state of the immune system;
feelings of anxiety.

These disorders are not permanent and disappear when the drug is discontinued.

Overdose

The phenomena of an overdose of trimebutine are not described, since there are no registered cases of taking an overdose that would lead to negative consequences.

Attention! In case of accidental excess of the dosage, it is recommended to induce vomiting - to minimize the risk of developing pathological processes.

Similar drugs

Alternative drugs are available at the pharmacy that can replace Trimedat. At the same time, analogues of the drug are divided into two groups depending on the compounds included in the composition:

Medicines containing trimebutine as the main active ingredient:

Neobutin is a structural analogue of Trimedat. Produced in Russia, has similar indications and contraindications for use.
Debridate - the advantage is the presence of a liquid dosage form - a suspension. This allows you to safely use the drug in infancy.

Medicines that have a similar medicinal effect, but have different components in the composition:

Duspatalin - relieves spasm of the small and large intestines, is also effective in chronic inflammation of the pancreas (pancreatitis) and colic of various origins.
Niasmam is used in the complex treatment of intestinal and biliary colic, as well as in irritable bowel syndrome. Among the side effects, in addition to allergies, dizziness was noted.
Irmalax - contains crushed psyllium husks. The therapeutic effect is based on the ability of fiber to absorb toxic metabolic products in the intestines, reduce the density of feces and promote bowel movement.
Bactistatin - eliminates the consequences of dysbacteriosis, manifested in the form of insufficient food processing. Normalizes bowel function, relieving bloating, constipation, pain. It is recommended as part of the complex therapy of diseases of the digestive tract.